Abcam, ab154818, Anti-PIP5K1 beta antibody [EPR9268]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PIP5K1 beta antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9268,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The phosphatidylinositol-4-phosphate 5-kinase type 1 beta (PIP5K1β) also known as PIPK type I beta is an enzyme that plays an important role in the synthesis of phosphatidylinositol 45-bisphosphate (PIP2) from phosphatidylinositol 4-phosphate (PI4P). This enzyme has a molecular weight of approximately 68 kDa. It expresses across various tissues with significant presence in the brain and in hematopoietic cells. The PIP5K1β enzyme is important in regulating the levels of PIP2 a critical lipid in membrane dynamics and signaling.
Biological function summary
PIP5K1β acts within the phosphoinositide signaling pathway which is essential for a range of cellular processes including actin cytoskeleton organization vesicle trafficking and cell survival. It forms part of a complex with other kinases and phosphatases that modulate cellular lipid concentrations. PIP5K1β also contributes to signal transduction processes by participating in the recruitment and activation of proteins that respond to membrane-associated signals.
Pathways
PIP5K1β is heavily involved in the regulation of the phosphoinositide 3-kinase (PI3K) pathway and the actin cytoskeleton pathway. Its product PIP2 serves as a substrate for PI3K which generates phosphatidylinositol-345-trisphosphate (PIP3) an important signaling molecule. PIP5K1β therefore indirectly impacts pathways that involve proteins like AKT and Rac1 which are important to cellular growth and motility.
PIP5K1β connects to cancer and immune system-related disorders. Dysregulation of PIP5K1β activity can lead to aberrant PI3K signaling contributing to oncogenic processes. Additionally it affects proteins such as AKT which plays a role in tumor progression and survival. In immune disorders altered PIP5K1β levels can impact the actin cytoskeleton affecting immune cell dynamics and function.