Abcam, ab154832, Anti-Foxo6 (phospho S184) antibody [EPR6863]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FOXO6 phospho S184 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6863,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Foxo6 protein also known as Forkhead box O6 is part of the Forkhead family of transcription factors characterized by a distinct forkhead DNA-binding domain. It has a molecular weight of approximately 68 kDa. Foxo6 is primarily expressed in the brain with significant presence in the hippocampus which plays an essential role in cognitive functions. Functionally Foxo6 regulates gene expression by binding to specific DNA sequences influencing various cellular processes including apoptosis metabolism and oxidative stress response.
Biological function summary
The regulatory activity of Foxo6 is important for maintaining neural integrity and proper brain function. It does not work as part of a larger complex but influences the expression of genes involved in cell cycle arrest longevity and stress resistance. Researchers have observed Foxo6 activity to affect synaptic function and plasticity in neurons which are critical for learning and memory processes. Its role in transcriptional regulation highlights its significance in managing cellular homeostasis and response to environmental changes.
Pathways
Foxo6 acts within the insulin signaling and PI3K/AKT pathways which are central to regulating growth proliferation and survival. Through these pathways Foxo6 interacts with proteins like AKT1 and 14-3-3 which modulate its activity by nuclear-cytoplasmic shuttling or degradation. The balance of Foxo6 activity within these pathways influences how cells respond to insulin and manage oxidative stress linking it to metabolic and stress response processes.
Aberrant Foxo6 activity links to neurodegenerative disorders and metabolic syndromes. In the context of Alzheimer's disease Foxo6 dysfunction may contribute to impaired cognition and synaptic deficits as its regulatory influence is important for neural health. Additionally altered Foxo6 signaling can affect insulin sensitivity relevant in conditions like type 2 diabetes as it connects through the insulin signaling pathway. These connections position Foxo6 as a potential therapeutic target for ailments associated with metabolic and cognitive impairments.