Abcam, ab155278, Anti-SAR1B + SAR1A antibody [EPR10105(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SAR1B antibody. Suitable for IHC-P, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Recombinant full length protein - Human, Mouse, Rat samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10105(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAR1B also known as Secretion-Associated RAS Related GTPase 1B is a small GTPase protein with a molecular mass of approximately 22 kDa. This protein plays an important role in intracellular trafficking specifically in the transport of proteins from the endoplasmic reticulum to the Golgi apparatus. SAR1B is expressed in various tissues with a higher presence in liver and small intestine cells where it participates in the regulation of lipoprotein assembly and secretion.
Biological function summary
SAR1B is essential for the formation of the coat protein complex II (COPII) facilitating the export of proteins in vesicles from the endoplasmic reticulum. As part of this COPII complex SAR1B assists in the scission of transport vesicles allowing their movement towards the Golgi apparatus. The interaction with other proteins such as SEC23 and SEC24 enhances the specificity of protein selection for transport which is necessary for proper cellular function.
Pathways
Several important interactions include SAR1B's role in the lipid metabolism and secretion pathways. It collaborates within these pathways to ensure the efficient transport of lipids and proteins necessary for maintaining lipid homeostasis. SAR1B works in coordination with other proteins such as SEC24 and SEC23 underlining its importance in these pathways that are critical for metabolic regulation.
Mutations in SAR1B have been linked with chylomicron retention disease also known as Anderson's disease. This condition is characterized by defective chylomicron secretion leading to symptoms such as fat malabsorption and low blood cholesterol levels. The disease highlights SAR1B's involvement with proteins ensuring proper lipid transport like APOB and MTTP emphasizing its contribution to lipid processing and systemic lipid balance.