Abcam, ab155323, Anti-TTPA/TPP1 antibody

Size: 100µL
Rabbit Polyclonal TTPA/TPP1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TTPA aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TTPA aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P49638

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TTPA also known as tocopherol (alpha) transfer protein and TPP1 is a protein with a mass of approximately 32 kDa. The protein binds to alpha-tocopherol a type of vitamin E and facilitates its transfer to cellular membranes. TTPA is mainly expressed in the liver but also found in smaller amounts in the brain lungs and other tissues. The protein ensures the efficient distribution of vitamin E throughout the body playing a significant role in maintaining cellular health.
Biological function summary
In many organisms TTPA acts as an important transporter of vitamin E helping protect cells against oxidative damage by delivering it to sites where it acts as an antioxidant. While not formally part of a recognized complex the protein interacts with cellular membranes as it transfers alpha-tocopherol. The function supports cell protection and injury prevention by ensuring an adequate supply of this essential vitamin.
Pathways
Vitamin E's movement within the body is directly influenced by TTPA's activity placing the protein within the tocopherol transport and metabolism pathways. The interaction with other antioxidant systems like the glutathione pathway highlights TTPA's importance in cellular redox homeostasis. TTPA-related proteins such as vitamin E-binding proteins modulate this transport and influence overall oxidative stress responses.
Mutations in the TTPA gene can lead to a rare neurodegenerative disorder known as ataxia with vitamin E deficiency (AVED). This condition highlights the critical need for functional TTPA in neurological health. Additionally research has linked TTPA to liver-related conditions where an association is found with lower levels of vitamin E and liver damage emphasizing its role as a protector of liver tissues. Understanding these connections helps target TTPA-related pathways and proteins such as APOB for potential therapeutic interventions.