Abcam, ab155482, Anti-eIF4GII antibody - N-terminal

Size: 100µL
Rabbit Polyclonal eIF4GII antibody. Suitable for ICC/IF, WB, IHC-P, IP and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Eukaryotic translation initiation factor 4 gamma 3 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IP, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Eukaryotic translation initiation factor 4 gamma 3 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.O43432

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The eukaryotic translation initiation factor 4GII (eIF4GII) also known as p97 plays an important role in the initiation of translation by acting as a central scaffold protein. With a molecular mass of approximately 160 kDa eIF4GII coordinates the assembly of the eIF4F translation initiation complex by interacting with other initiation factors and RNA. This protein is ubiquitously expressed across various tissues highlighting its fundamental role in protein synthesis.
Biological function summary
EIF4GII is integral to mRNA translation by facilitating the formation of the eIF4F complex which includes eIF4E eIF4A and itself. This complex binds to the 5' cap structure of mRNA an essential step for ribosome recruitment. eIF4GII performs functions important to translation regulation and cellular growth control influencing processes like cell proliferation and survival. Its activity links to mechanistic target mTOR signaling a pathway key to many cellular events.
Pathways
EIF4GII has significant involvement in the mTOR signaling pathway a major regulator of cell growth proliferation and protein synthesis. It operates alongside proteins such as eIF4E and eIF4A in this pathway facilitating the promotion of cap-dependent translation. eIF4GII also ties into the PI3K/AKT/mTOR axis influencing processes that control cell cycle progression and energy metabolism showing its role in the regulation of nutrient-sensitive signals.
EIF4GII has implications in cancer and neurodegenerative diseases linked through its control of protein synthesis. Aberrant expression or regulation of eIF4GII can lead to uncontrolled cell proliferation and survival common in various cancers. In these contexts proteins like mTOR and eIF4E interact with eIF4GII in oncogenic pathways. In neurodegenerative disorders altered translation initiation involving eIF4GII contributes to the pathogenesis impacting neuronal survival and function due to defective protein synthesis control.