Abcam, ab155992, Anti-TIP-1 antibody [EPR7900(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TIP-1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7900(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The mouse and rat recommendation is based on the WB results. We do not guarantee IHC-P for mouse and rat.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TIP-1 also known as Tax-interacting protein-1 or glutaminase-interacting protein (GIP) is a small protein with a mass of approximately 14.5 kDa. It functions mechanically by binding to PDZ domains found in a wide range of cellular proteins. TIP-1 expression occurs in various tissues with notable presence in the brain liver and kidney. Its ability to interact with PDZ domain-containing proteins plays an important role in cellular maintenance and signaling.
Biological function summary
TIP-1 functions as a regulator of cellular signaling pathways through its interaction with PDZ-domain proteins. It does not typically form part of a larger protein complex but rather acts as an independent modulator. TIP-1 influences cellular signaling by affecting the spatial arrangement of proteins in cells thereby impacting signal transduction mechanisms. This regulation can affect various biological processes including cell proliferation and apoptosis.
Pathways
TIP-1 plays a role in the Wnt signaling pathway where it interacts with proteins such as Dishevelled which is important for transducing Wnt signals. TIP-1 also has implications in the glutamate metabolic pathway by interacting with proteins like glutaminase. These pathways are essential for cellular growth processes and energy metabolism regulation showing the interconnectivity of TIP-1 with key cellular functions.
TIP-1 implicates itself in cancer and neurological disorders. Overexpression of TIP-1 has been associated with certain types of cancer where it may interact with proteins like β-catenin to impact cell proliferation and migration. In neurological disorders dysfunction in TIP-1's interactions within signaling pathways may contribute to diseases such as schizophrenia closely linked with disturbed glutamate signaling and TIP-1's PDZ domain interactions.