Abcam, ab155999, Anti-SDHC antibody [EPR11035(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SDHC antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 16 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11035(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SDHC also known as succinate dehydrogenase complex subunit C or succinate dehydrogenase cytochrome b560 subunit is an integral component of the mitochondrial complex II. It has a mass of approximately 15.3 kDa. SDHC is embedded in the inner mitochondrial membrane and is expressed in various tissues with a high mitochondrial content including skeletal muscle heart and brain. Mechanically SDHC anchors the succinate dehydrogenase (SDH) complex to the mitochondrial membrane facilitating effective electron transport during cellular respiration.
Biological function summary
The subunit SDHC plays a role in the conversion of succinate to fumarate in the tricarboxylic acid (TCA) cycle. By being part of the larger succinate dehydrogenase complex which also functions as part of the electron transport chain SDHC contributes to both energy production and metabolic regulation within cells. The SDH complex consists of four subunits: SDHA SDHB SDHC and SDHD. SDHC serving as an integral membrane protein ensures the proper anchoring and assembly of the complex which is essential for efficient electron transfer.
Pathways
SDHC is involved in both the TCA cycle and the mitochondrial electron transport chain. Within these pathways it enables the transfer of electrons from succinate to ubiquinone connecting two primary bioenergetic pathways. SDHC exhibits a relationship with other complex II subunits such as SDHA which catalyzes the oxidation reaction of succinate to fumarate. The electron flow through SDHC has an impact on the entire process of oxidative phosphorylation ultimately influencing ATP production in cells.
SDHC mutations and dysfunctions have links to conditions such as paragangliomas and pheochromocytomas. These tumors are associated with altered cellular metabolism and abnormal SDH complex activity. Mutations in the SDHC gene can lead to a disruption of normal electron transport chain function causing oxidative stress and contributing to tumorigenesis. Moreover SDHC mutations often co-occur with alterations in other SDH complex components such as SDHB further emphasizing the role of this complex in certain disease states.