Abcam, ab156699, Anti-LIMKAIN B1 antibody

Size: 100µg
Rabbit Polyclonal LIMKAIN B1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MARF1 aa 1600-1700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MARF1 aa 1600-1700. The exact immunogen used to generate this antibody is proprietary information.Q9Y4F3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab156699 was affinity purified using an epitope specific to LIMKAIN B1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIMKAIN B1 also called LAS1L is a protein with a mass of approximately 35 kDa. The protein plays a role in ribosome biogenesis and is an essential factor in the nucleoplasmic assembly of pre-ribosomal particles. LIMKAIN B1 is mainly expressed in the nucleus of the cell where it associates with other ribosomal proteins and RNAs to ensure proper ribosome function and production.
Biological function summary
LIMKAIN B1 affects the production and assembly of ribosome components by associating with the Las1L complex. The protein’s activity is required for the processing of 28S rRNA highlighting its importance in ribosome maturation. This processing step happens in the final stage of ribosome biogenesis and disruptions in LIMKAIN B1 function can lead to the accumulation of unprocessed ribosomal RNA impairing the formation of functional ribosomal units.
Pathways
LIMKAIN B1 has significant roles in the ribosome biogenesis and cell proliferation pathways. The protein monitors rRNA processing and ribosome assembly within the nucleolus. LIMKAIN B1 works closely with NOL9 a protein involved in 28S rRNA cleavage to regulate the synthesis of ribosomes. Such coordination ensures that ribosome production matches the overall cellular demand for protein synthesis.
Mutations in LIMKAIN B1 are linked to certain types of cancer and ribosomopathies. Alterations in its function can lead to defective ribosome production contributing to the pathogenesis of ribosomopathies. In the context of cancer LIMKAIN B1 influences the expression of oncoproteins through its relation to Myc a protein that drives cell cycle progression and growth. This association highlights its potential impact on both cancer development and the regulation of cellular growth processes.