Abcam, ab156783, Anti-IL36 gamma/IL-1F9 antibody [OTI2F4]

Size: 100µL
Anti-IL36 gamma/IL-1F9 antibody [OTI2F4] (ab156783) is a mouse monoclonal antibody detecting IL36 gamma/IL-1F9 in Western Blot, IHC-P, ICC/IF . Suitable for Human . - Over 10 publications
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI2F4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human IL36G.Q9NZH8

Product details:
What is this antibody validated in?
Anti-IL36 gamma/IL-1F9 antibody [OTI2F4] (ab156783) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples.
What is the molecular weight of IL36 gamma/IL-1F9?
Anti-IL36 gamma/IL-1F9 [OTI2F4] (ab156783) specifically detects a band for IL36 gamma/IL-1F9 (UniProt: Q9NZH8) at a molecular weight of 19kDa.
Trusted by the scientific community
Anti-IL36 gamma/IL-1F9 [OTI2F4] (ab156783) was first used in a scientific publication in 2013 and has been cited over 10 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab156783 is purified from TCS by affinity chromatography, Storage buffer-pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IL36 gamma also known as IL-1F9 or IL-36 is a member of the interleukin-1 cytokine family. The protein weighs approximately 22 kDa. It is expressed highly in epithelial tissues such as keratinocytes in the skin bronchial tissues and intestinal lining. It acts mainly on nearby cells to influence immune responses through cytokine signaling.
Biological function summary
IL36 gamma plays a role in the immune and inflammatory responses. It operates as a cytokine that signals through the IL-1 receptor family leading to the activation of NF-kB and MAPK pathways. This member of the IL-1 family does not form a complex by itself but interacts with IL-36R to exert its functions. The protein influences processes such as cell proliferation differentiation and the regulation of immune responses to external pathogens or injuries.
Pathways
IL36 gamma is involved in inflammatory and immune signaling pathways. Within the immune response pathway it stimulates the production of other cytokines and pro-inflammatory molecules. IL36 gamma is associated with the IL-1 signaling pathway alongside other cytokines such as IL-1 and IL-18 which all contribute to immune modulation and inflammatory responses.
IL36 gamma has connections to psoriasis and inflammatory bowel disease. In psoriasis increased levels of IL36 gamma correlate with heightened skin inflammation and proliferation of keratinocytes. In inflammatory bowel disease IL36 gamma contributes to the inflammatory state of the gut. The activities of IL36 gamma often link with other cytokines such as TNF-alpha which collectively drive the inflammatory processes observed in these conditions.