Abcam, ab157101, Anti-Ribosomal protein S11/RPS11 antibody

Size: 100µg
Rabbit Polyclonal Ribosomal protein S11/RPS11 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human 40S ribosomal protein S11 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human 40S ribosomal protein S11 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P62280

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab157101 was affinity purified using an epitope specific to Ribosomal protein S11/RPS11 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ribosomal protein S11 also known as RPS11 or BSA S11 is a component of the small 40S subunit of ribosomes. It has a mass of about 18.8 kDa. RPS11 is expressed across various tissues essential for protein synthesis in eukaryotic cells. It plays a mechanical role in facilitating the assembly and proper function of the ribosome which is critical for translating mRNA into protein.
Biological function summary
RPS11 serves as an important player in the ribosomal complex vital for maintaining the structure and function of the ribosome. It assists in the binding of mRNA and tRNA promoting the translation process. The precise arrangement of RPS11 and its interactions with other ribosomal proteins ensures efficient protein synthesis necessary for cell growth and function.
Pathways
RPS11 plays a significant role in the translation mechanism including the mTOR pathway which regulates cell growth in response to nutrients and growth factors. Through this pathway RPS11 works in conjunction with proteins like S6 kinase and 4E-BP1 modulating protein translation rates in various cellular conditions. Additionally RPS11 contributes to the ribosomal biogenesis pathway integrating signals for assembly and function of ribosomes.
Disruptions in RPS11 regulation or mutations can lead to conditions such as Diamond-Blackfan anemia characterized by reduced red blood cell production. RPS11's interaction with other ribosomal proteins like RPS19 has been implicated in this disorder. Moreover altered expression of RPS11 may play a role in various cancers influencing tumor growth and malignancy due to abnormal protein synthesis rates.