Abcam, ab157111, Anti-RPL26 antibody

Size: 100µg
Goat Polyclonal RPL26 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RPL26 aa 50 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RPL26 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P61254

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPL26 also known as Ribosomal Protein L26 is a component of the 60S subunit of the ribosome. It has a mass of approximately 17 kDa. This protein primarily expresses in tissues with high levels of protein synthesis including muscle liver and brain. As part of the ribosome RPL26 plays an essential role in the synthesis of proteins by facilitating the assembly of amino acids into polypeptide chains.
Biological function summary
RPL26 contributes to the complex process of translation by ensuring the stability and proper function of the ribosome. As a structural part of the large ribosomal subunit it helps maintain the integrity of the ribosomal architecture necessary for effective translation. This protein also indirectly affects mRNA processing and mRNA stability both of which influence the efficiency of protein synthesis.
Pathways
RPL26 participates in translation and ribosome biogenesis pathways. It interacts closely with other ribosomal proteins and rRNA to form the functional ribosome. Within these pathways RPL26 is linked with proteins like RPL5 and RPL11 which also contribute to the assembly and stability of the ribosome. Efficient protein synthesis by this pathway is fundamental for cellular growth and proliferation.
RPL26 is associated with conditions like Diamond-Blackfan anemia and cancer. Diamond-Blackfan anemia is a ribosomopathy resulting from mutations in ribosomal proteins including RPL26 disrupting normal erythropoiesis. The depletion or malfunction of RPL26 can also influence cancer progression by altering the translational capacity of cancer cells affecting proteins like p53 that control cell cycle and apoptosis.