Abcam, ab157593, Anti-Ephexin-1 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal Ephexin-1 antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Mouse Ephexin-1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat, Mouse,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Ephexin-1. The exact immunogen used to generate this antibody is proprietary information.Q8CHT1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ephexin-1 also referred to as NGEF (neuronal guanine nucleotide exchange factor) acts as a guanine nucleotide exchange factor (GEF) that specifically activates Rho GTPases by promoting the exchange of GDP for GTP. Ephexin-1 has an approximate mass of 70 kDa. Its expression is widely observed in various tissues with significant levels in the nervous system where it plays important roles in neural development and function.
Biological function summary
Ephexin-1 plays a role in cytoskeletal reorganization by modulating the activity of Rho GTPases which are critical regulators of actin dynamics. It is part of molecular complexes that help control axon guidance and synapse formation in neurons. Through these functions Ephexin-1 influences cell shape motility and growth.
Pathways
Ephexin-1 interacts with neural pathways such as the ephrin signaling pathway. It acts in conjunction with proteins like Eph receptors which are important for cell-cell communication and guidance during developmental processes. Another pathway includes the Rho/ROCK signaling cascade where Ephexin-1 activity leads to changes in actin cytoskeleton dynamics and influences cellular morphology.
Alterations in Ephexin-1 function have been linked to neurodevelopmental disorders and cancers. Mutations or abnormal expression of Ephexin-1 can affect the balance of signaling pathways and cause disruptions in normal neural function. It also relates to conditions like schizophrenia where Eph receptors are also implicated highlighting the interconnected network between Ephexin-1 and Eph receptors in disease etiologies.