Abcam, ab157987, Recombinant Human C4BPA protein

Size: 10µg
Recombinant Human C4BPA protein is a Human Full Length protein, in the 49 to 597 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P04003,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C4BPA also known as C4b-binding protein alpha chain is an important component in the immune system. It has a molecular mass of approximately 570 kDa. This protein is mainly expressed in the liver and is secreted into the plasma. C4BPA functions by binding to complement component 4b which is a part of the complement system responsible for managing immune responses and clearing pathogens.
Biological function summary
C4BPA plays a significant role in the regulation of the complement cascade specifically the classical and lectin pathways. It acts as a cofactor for factor I-mediated cleavage of C4b thereby inhibiting the progression of the complement activation. C4BPA forms a complex with other proteins such as C4BPB and this complex is essential for regulating the complement system and preventing damage to host cells.
Pathways
C4BPA is deeply involved in both the classical and lectin complement pathways. These pathways are important for antigen clearance and inflammation. C4BPA works together with proteins like complement component 3 (C3) to efficiently regulate these pathways preventing excessive complement activation. It associates with downstream effectors maintaining balance in immune defense mechanisms and inflammation control.
C4BPA shows significant connections to autoimmune diseases and infections. Deficiencies or malfunctions in C4BPA can lead to conditions such as systemic lupus erythematosus where its regulatory role on complement activation becomes compromised. In infections C4BPA interacts with proteins like factor H playing a role in modulating host responses to prevent tissue damage. Understanding the interactions and regulatory processes involving C4BPA is important for developing therapeutic strategies for these conditions.