Abcam, ab159283, Recombinant Human Thymosin alpha 1 protein

Size: 10µg
Recombinant Human Thymosin alpha 1 protein is a Human Full Length protein, in the 1 to 110 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P06454,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Thymosin alpha 1 also known as Tα1 is a peptide with a molecular weight of approximately 3108 Daltons. It is expressed within the thymus an organ critical for T cell maturation. Structurally Tα1 consists of 28 amino acid residues and functions through interactions with the immune cells. As a result it engages in various roles to stimulate immune responses and bolster the body's defense mechanisms against pathogens.
Biological function summary
Thymosin alpha 1 stimulates the maturation and differentiation of T cells central players in the adaptive immune response. It organizes these cells to enhance their capability to recognize antigens and react to infections or abnormal cells. Thymosin alpha 1 does not form part of any known larger complexes but independently precipitates a cascade of immune-related activities. These actions establish thymosin alpha 1 as an important regulatory molecule in the immune system.
Pathways
The biological function of thymosin alpha 1 is integrated into the immune response pathways. It is notably involved in the T cell receptor signaling pathway contributing to the activation and proliferation of T cells. Thymosin alpha 1 associates closely with proteins such as interleukin-2 and interferon-alpha which are critical to these immune pathways. Together these molecules reinforce the immune defense by promoting cell-mediated immunity in the presence of antigens.
Thymosin alpha 1 shows relevance to infectious diseases including hepatitis B and C where it supports antiviral responses. It also displays therapeutic potential in cancer treatment enhancing the efficacy of certain therapies. Moreover thymosin alpha 1 interacts with proteins like interleukin-2 in these disease contexts working to improve immune surveillance and control malignant cell growth and viral spread.