Abcam, ab159663, Recombinant Human TEAD3 protein

Size: 10µg
Recombinant Human TEAD3 protein is a Human Full Length protein, in the 1 to 324 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q99594,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TEAD3 also known as TEF-5 is a transcription factor that plays an important role in regulating gene expression. It belongs to the TEA/ATTS domain family and has a molecular mass of around 47 kDa. This protein is expressed in several tissues including the heart liver and skeletal muscle suggesting its involvement in various cellular functions across different organ systems. The mechanical action of TEAD3 involves binding to DNA sequences within the nucleus to modulate transcription of target genes.
Biological function summary
TEA/ATTS domain family members like TEAD3 activate transcription of genes involved in proliferation and differentiation. TEAD3 partners with co-factors such as YAP (Yes-associated protein) to form a complex that influences gene expression patterns critical for cellular growth and development. The interactions between TEAD3 and its co-factors play a significant role in mediating pathways that sustain normal tissue function and adaptation.
Pathways
Numerous cellular functions hinge on the YAP-TEAD3 interaction a focal point of the Hippo signaling pathway which governs cell growth apoptosis and the stem cell population. In addition TEAD3 features in the Wnt signaling pathway thereby affecting processes of embryogenesis and tissue regeneration. Through these pathways TEAD3 connects with other proteins like TAZ (transcriptional coactivator with PDZ-binding motif) and β-catenin to mediate signal transduction and cellular response.
TEAD3's deregulation links to various cancers and fibrotic diseases. Aberrant activity in the Hippo pathway involving TEAD3 and YAP has been observed in hepatocellular carcinoma contributing to unchecked cellular proliferation and survival. Similarly in renal fibrosis altered TEAD3 activity impacts the expression of fibrotic markers often observed with changes in the TGF-β (transforming growth factor-beta) signaling pathway. Understanding these relationships can offer insights into developing therapeutic strategies targeting TEAD3 interactions in disease contexts.