Abcam, ab160279, Recombinant Human USP13 protein

Size: 10µg
Recombinant Human USP13 protein is a Human Full Length protein, in the 1 to 863 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q92995,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP13 also known as Ubiquitin Specific Protease 13 functions as a deubiquitinating enzyme. It is important in removing ubiquitin molecules from protein substrates which prevents them from being degraded by the proteasome system. USP13 has a molecular mass of approximately 97 kDa and shows expression in several tissues including brain heart and kidney. This indicates its diverse role in human physiology.
Biological function summary
USP13 participates in maintaining protein homeostasis and modulates protein stability. It forms complexes with specific substrate proteins to execute its function efficiently. Through deubiquitinating actions it regulates the levels of proteins involved in cellular signaling apoptosis and cell cycle control. The enzyme influences processes that are important for cell survival and adaptation to stress.
Pathways
USP13 plays significant roles within the ubiquitin-proteasome system and the mitophagy pathway. It cooperates with proteins like Parkin in mitochondrial quality control by stabilizing target proteins necessary for mitophagy. Through interaction with key players in these pathways USP13 ensures the maintenance of cellular health and proper degradation of damaged or misfolded proteins.
USP13 has associations with cancer and neurodegenerative diseases. Overexpression of USP13 might contribute to tumor progression by inhibiting degradation of oncoproteins. It also shows connections to disorders like Parkinson's disease where it interacts with proteins such as Parkin and PINK1 which are important for mitochondrial function. These interactions highlight USP13's potential as a target for therapeutic interventions.