Abcam, ab160624, Recombinant Human FAM131B protein

Size: 10µg
Recombinant Human FAM131B protein is a Human Full Length protein, in the 1 to 332 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q86XD5,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM131B also known as Family with Sequence Similarity 131 Member B is a 33 kDa protein. It is expressed in various tissues including the heart liver and skeletal muscles. The protein is intracellular and appears to play a role in cellular processes by interacting with other proteins involved in signaling pathways.
Biological function summary
The FAM131B protein contributes to cellular growth and regulation. It can form complexes with other cellular proteins to modulate their activity. This function suggests that FAM131B might have a hand in orchestrating cellular responses to environmental stimuli assisting cells to adapt and respond effectively.
Pathways
FAM131B is involved in protein kinase signaling and gene expression regulation. It interacts with proteins such as RET and ELK1 which are essential for signal transduction and transcription regulation. This participation indicates that FAM131B acts as a mediator in pathways that influence cellular differentiation and development.
Studies have shown the involvement of FAM131B in certain types of cancer especially thyroid carcinoma. The protein forms a fusion with RET to create the RET/PTC rearrangement which leads to tumor development. In fibrolamellar hepatocellular carcinoma it associates with DNAJB1 suggesting a role in tumorigenesis by contributing to abnormal gene regulation.