Abcam, ab161115, Recombinant Human TCP1 theta protein

Size: 10µg
Recombinant Human TCP1 theta protein is a Human Full Length protein, in the 1 to 27 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P50990,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TCP1 theta also known as CCT8 is a chaperonin protein that plays a critical role in assisting the folding of newly synthesized and stress-denatured proteins. With a molecular mass of approximately 59 kDa TCP1 theta is an essential component of the chaperonin-containing TCP1 (CCT) complex also referred to as the TRiC complex. It is found primarily in the cytoplasm and is expressed in various tissues with high levels noted in the brain liver and testis.
Biological function summary
TCP1 theta functions within the CCT complex to facilitate the proper folding of proteins particularly actin and tubulin which are vital for maintaining cellular structure and function. By ensuring correct protein folding TCP1 theta helps prevent aggregation that could lead to cellular dysfunction. This chaperonin is part of a large complex that cooperates with other chaperonins to stabilize newly synthesized polypeptides and mediate their conformational maturation.
Pathways
TCP1 theta is integral to the protein folding pathway and actively participates in cytoskeletal organization. TCP1 theta interacts closely with proteins like actin and tubulin aiding in their folding and stabilization. Its activity supports the function of the cytoskeleton influencing cell shape and transport processes. The protein folding pathway in which TCP1 theta plays an important role is essential for proper cellular function and response to stress.
Malfunction or dysregulation of TCP1 theta contributes to conditions such as cancer and neurodegenerative diseases. In cancer abnormal expression of TCP1 theta may support tumor progression and cell survival by aiding in the folding of proteins required for rapid cell division. Additionally its role in neurodegenerative diseases connects to alterations in protein homeostasis often exacerbating disorders like Alzheimer's disease. Proteins involved in these diseases such as tau in Alzheimer's may rely on TCP1 theta for correct folding linking its function to pathogenesis.