Abcam, ab161187, Recombinant Human C1QL1 protein

Size: 10µg
Recombinant Human C1QL1 protein is a Human Full Length protein, in the 1 to 258 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O75973,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C1QL1 also known as complement C1q-like protein 1 is a member of the C1q protein family. It has an approximate mass of 26 kDa. This protein is primarily expressed in the brain most notably in the cerebellum indicating its role in central nervous system processes. Researchers often investigate C1QL1 because of its structural similarities to complement components despite its distinct function within the neurological context.
Biological function summary
C1QL1 participates in synapse regulation and the maintenance of synaptic plasticity. It forms a part of a larger complex involving several other C1q-like proteins. These complexes contribute to the modulation of synapse formation and pruning by interacting with receptors on post-synaptic neurons. C1QL1's ability to influence synaptic connectivity makes it an important factor in cognitive development and neuroplasticity aspects fundamental to neuronal network adaptations.
Pathways
C1QL1 engages in pathways related to neural development and synaptic signaling. One significant pathway includes the complement cascade where its role diverges from traditional immune functions to support neural development. C1QL1 associates with proteins such as BAFF and APRIL through this pathway. It also plays a part in modulating the Wnt signaling pathway contributing to neuronal positioning and circuitry refinement.
C1QL1 has links to neurological conditions such as autism spectrum disorders and schizophrenia. Its role in synapse formation and plasticity makes it a significant factor in these disorders both characterized by altered synaptic connectivity. Connections to proteins such as NLGN1 and SHANK3 show how alterations in C1QL1 expression or function may lead to disruptions in synaptic balance highlighting its importance in maintaining normal cognitive function.