Abcam, ab162780, Recombinant Human WDR5B protein

Size: 10µg
Recombinant Human WDR5B protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q86VZ2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR5B also known as WD repeat-containing protein 5B is a protein involved in chromatin modification. This protein has a molecular mass of approximately 38 kDa. It expresses in various tissues with notable expression in reproductive tissues and certain types of cancer cells. WDR5B has the ability to bind to other proteins through its WD40 repeats facilitating protein-protein interactions essential for its function.
Biological function summary
WDR5B participates in the regulation of gene expression. It acts as a component of chromatin remodeling complexes assisting in the modification of histone proteins. This function suggests that WDR5B plays a role in epigenetic regulation impacting processes like cell proliferation and differentiation. In these complexes WDR5B enables the formation of stable structures that modify the accessibility of transcriptional machinery to DNA.
Pathways
WDR5B plays important roles in the regulation of the cell cycle and DNA damage response pathways. It interacts with proteins such as MYC and MLL1 influencing processes that control cell division and the maintenance of genomic integrity. Through these pathways WDR5B contributes to the regulation of genes that ensure proper cell cycle progression and repair of damaged DNA.
Researchers have shown interest in WDR5B due to its association with cancer and developmental disorders. WDR5B's interaction with MYC proteins can enhance oncogenic pathways promoting tumorigenesis in certain cancers. Furthermore dysregulation of WDR5B can be linked to developmental disorders where abnormal chromatin remodeling affects gene expression patterns important for normal development. Researchers continue to explore WDR5B's potential as a therapeutic target in these diseases.