Abcam, ab162865, Recombinant Human EPS8L1 protein

Size: 10µg
Recombinant Human EPS8L1 protein is a Human Full Length protein, in the 1 to 551 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8TE68,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPS8L1 also known as Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 1 is a protein that weighs approximately 82 kDa. This protein is a member of the EPS8 family known for its capacity to modulate signaling pathways related to cell growth and differentiation. EPS8L1 exhibits expression in various tissues but shows significant expression in epithelial tissues. It plays a mechanical role in linking receptor tyrosine kinases to downstream signaling cascades.
Biological function summary
EPS8L1 contributes to the regulation of actin cytoskeleton dynamics. This protein forms part of a complex with other scaffold proteins impacting cell migration and adhesion processes. Through this role EPS8L1 influences cellular shape and motility which affects tissue organization and repair. Its function in modulating actin structure makes it an important player in maintaining proper cellular architecture.
Pathways
EPS8L1 participates in the EGFR signaling pathway where it acts to mediate the effects of growth factors on cellular mechanics. This pathway includes the interactions of EPS8L1 with proteins such as EGF receptor and SOS1 connecting extracellular signals to intracellular responses that drive proliferation and survival. Additionally EPS8L1 operates within the MAPK/ERK pathway further linking it to cellular growth and differentiation stimuli by interacting with Ras family proteins.
Alterations in EPS8L1 function and expression have associations with cancerous developments particularly involving epithelial-derived tumors. Its interactions with the EGFR and other related receptor proteins contribute to tumor progression and metastasis. Additionally EPS8L1's role in cytoskeletal regulation links it to neurodegenerative diseases where impaired cellular architecture affects neuronal survival and function. These associations highlight the importance of EPS8L1 in maintaining cellular homeostasis and its potential as a therapeutic target.