Abcam, ab162978, Recombinant Human CEP27 protein

Size: 10µg
Recombinant Human CEP27 protein is a Human Full Length protein, in the 1 to 235 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9NVX0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP27 also known as Centrosomal protein 27 or CECR2 is a protein that mechanically plays a role in centrosome function and cell cycle regulation. It has a molecular mass of approximately 28 kDa. Researchers have found CEP27 expression across various human tissues with notable levels in the brain and heart. This protein localizes in the centrosome an important cellular structure involved in microtubule organization particularly during cell division.
Biological function summary
CEP27 contributes to the maintenance of cell structure and integrity. It forms part of the centrosome complex which is essential for the proper organization of the spindle apparatus during mitosis. The coordination of CEP27 with other centrosomal proteins ensures the correct segregation of chromosomes fundamental for normal cell proliferation. Disruption of its function can lead to errors in chromosome distribution highlighting its role in genetic stability.
Pathways
Scientists have found CEP27 functions within the framework of the cell cycle regulation and mitotic spindle assembly pathways. Its interaction with proteins such as CEP192 and CEP350 reinforces its involvement in centrosome cohesion and microtubule anchoring processes. These pathways are essential for correct cell cycle progression and division indicating CEP27's critical role in cellular replication and organization.
Variations in CEP27 are associated with certain cancers including glioblastoma and breast cancer. Its interaction with proteins like NEK2 and Aurora kinase A both implicated in oncogenesis suggests that CEP27 influences tumorigenic pathways. Aberrations in expression or function may contribute to uncontrolled cell proliferation making CEP27 a potential target for therapeutic intervention in cancer research.