Abcam, ab163458, Recombinant Human Tubby like protein 4

Size: 10µg
Recombinant Human Tubby like protein 4 is a Human Full Length protein, in the 1 to 678 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9NRJ4,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tubby like protein 4 (TULP4) also known by its alternate name TULP4 is a member of the tubby family of proteins. It has a molecular mass of approximately 62 kDa. TULP4 is expressed in several tissues but has notable expression in the brain and retinal tissues. Its structure includes a conserved C-terminal tubby domain which is likely involved in DNA binding alongside more variable N-terminal segments which differentiate it from other tubby-like proteins.
Biological function summary
Tubby-like proteins are involved in various cellular processes such as signal transduction and transcriptional regulation. TULP4 does not act in isolation; it forms part of protein complexes which interact with cell membranes and cytoskeletal components for carrying out its functions. These interactions help mediate intracellular signaling pathways that are essential for maintaining cellular homeostasis and function.
Pathways
Tubby like protein 4 participates in signaling and metabolic pathways most notably the Phosphatidylinositol 45-bisphosphate and PI3K/AKT pathways. Within these pathways TULP4 interacts with proteins like phosphoinositide which plays a role in modulating signal transduction. These pathways are essential for cell growth survival and metabolism and help in understanding how TULP4 regulates these biological processes.
Mutations and dysfunctions in tubby like protein 4 are associated with retinal degeneration and obesity-related conditions. Retinitis pigmentosa a disorder connected to retinal degeneration links TULP4's role within the retina to visual impairment. Similarly the protein may have ties with other proteins such as TUB and TULP1 which also relate to obesity pathways. Understanding TULP4's role in these conditions may offer insights into their underlying mechanisms and potential therapeutic targets.