Abcam, ab163864, Recombinant Human METT11D1 protein

Size: 10µg
Recombinant Human METT11D1 protein is a Human Full Length protein, in the 1 to 456 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9H7H0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
METTL11D also known as METT11D1 is a protein that functions as a methyltransferase. It plays an important role in the methylation of proteins specifically on lysine residues which adds a methyl group to these amino acids. METTL11D has a molecular weight of approximately 33 kDa. It is expressed in various tissues including the liver brain and kidney. This protein is intracellular predominantly found in the cytoplasm and nucleus of cells where it exerts its enzymatic functions.
Biological function summary
METTL11D is involved in post-translational modifications of histones and other proteins which affect their activity and interactions. These modifications can alter chromatin structure and regulate gene expression. METTL11D works as part of a larger methyltransferase complex interacting with co-factors to facilitate methylation processes. This protein’s activity can influence cellular processes like DNA repair and transcription regulation impacting cell growth and differentiation.
Pathways
METTL11D's methyltransferase function plays a role in the epigenetic pathway where it impacts chromatin modification. This pathway is important for regulating gene accessibility and transcription. METTL11D interacts with histones and other proteins such as SETD proteins to modulate gene expression through chromatin remodeling. Another significant involvement of METTL11D is in protein degradation pathways where methylation marks proteins for identification by the ubiquitin-proteasome system influencing protein stability and turnover.
METTL11D has been linked with cancer and neurodegenerative diseases. In cancer the protein's role in methylation can lead to dysregulation of gene expression patterns contributing to tumorigenesis and cancer progression. In some neurodegenerative conditions altered methylation of proteins where METTL11D functions may affect protein aggregation and neuronal survival. Moreover METTL11D's interaction with proteins like HDACs has implications in these diseases as they are also involved in maintaining proper histone acetylation and gene transcription balance.