Abcam, ab164813, Recombinant Human UCN2/SRP protein

Size: 10µg
Recombinant Human UCN2/SRP protein is a Human Full Length protein, in the 1 to 112 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q96RP3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
This product was previously labelled as UCN2.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UCN2 also known as urocortin 2 or stresscopin-related peptide (SRP) is a peptide hormone with a molecular weight of approximately 5 kilodaltons. This protein is abundant in several tissues including skeletal muscle and the central nervous system. It acts through the corticotropin-releasing factor receptor 2 (CRF2R) which is where UCN2/SRP exerts its effects. Due to its expression pattern UCN2/SRP holds significance in coordinating responses to stress and energy regulation.
Biological function summary
UCN2/SRP plays an important role in the modulation of cardiovascular function and energy homeostasis. It is part of a molecular complex with CRF2R initiating signaling that influences heart rate and blood pressure regulation. UCN2/SRP impacts thermogenic regulation and glucose metabolism indicating its role in energy balance. By interacting with CRF2R UCN2 may modulate anxiety-related behavior and help to mitigate stress responses due to changes in physiological states.
Pathways
UCN2/SRP participates in the stress-response pathway and the metabolic regulation pathway. Through the stress-response pathway it helps mediate the body's adaptive response to physical and psychological stress impacting the hypothalamic-pituitary-adrenal axis. In metabolic regulation UCN2/SRP works alongside proteins like corticotropin-releasing hormone (CRH) to control glucose levels and lipolysis. These pathways highlight the diverse influence of UCN2/SRP in managing bodily responses to environmental changes.
UCN2/SRP has been linked to conditions such as heart failure and metabolic syndrome. Increased expression of UCN2/SRP may provide protective effects in heart failure by enhancing cardiac output and reducing vascular resistance. In metabolic syndrome UCN2/SRP is associated with improved insulin sensitivity and lipid profiles working in part through its interaction with CRH. Understanding these connections helps in developing therapeutic strategies that target UCN2/SRP for the treatment of such disorders using techniques like 'anti-SRP antibodies' and their applications in clinical studies.