Abcam, ab164987, Recombinant Human PHF21B protein

Size: 10µg
Recombinant Human PHF21B protein is a Human Full Length protein, in the 1 to 531 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q96EK2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PHF21B also referred to as plant homeodomain finger protein 21B acts mechanically as a transcriptional repressor. It contains a PHD domain which helps it bind to specific histone modifications. The protein has an estimated mass of approximately 73 kDa. Expression of PHF21B occurs in various tissues particularly within the brain and pancreas indicating its potential significance in neurological and metabolic functions.
Biological function summary
PHF21B functions as an integral component of chromatin remodeling complexes that influence gene expression. By modulating chromatin architecture PHF21B participates in regulating accessibility of DNA to transcription factors thereby influencing transcriptional activity. It's a part of larger protein complexes but specific interactions with co-factors or complex components might involve various proteins that bind to modified histones impacting gene silencing efficiently.
Pathways
Several studies suggest that PHF21B is active in epigenetic regulation pathways mainly affecting histone modification pathways. It influences gene expression by altering the epigenetic landscape and interacts with proteins like HDACs and other histone methylation-related proteins. Additionally PHF21B is thought to influence neuron development pathways further supported by its expression in brain tissue where it partners with neurodevelopment-related proteins.
Research implicates PHF21B modifications in neurological disorders including neurodevelopmental delays and certain intellectual disabilities. Variants in PHF21B relate to autism spectrum disorders suggesting its role in synapse formation or maintenance may be important. Additionally misregulation of genes involving PHF21B and its interaction partners such as MECP2 may contribute to understanding complex genetic pathologies linked to neural development issues.