Abcam, ab165111, Recombinant Human GPCR TGR7 protein

Size: 10µg
Recombinant Human GPCR TGR7 protein is a Human Full Length protein, in the 1 to 321 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8TDS7,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The G protein-coupled receptor TGR7 also known as MrgA1 or MAS-related GPR weighs about 36 kDa. This receptor is a part of a large family of GPCRs involved in sensory perception. TGR7 exhibits expression mainly in sensory neurons particularly within dorsal root ganglia. Its mechanical function involves recognizing specific ligands which leads to activation of intracellular signaling cascades.
Biological function summary
TGR7 plays a role in pain transmission and modulation processes. The receptor is involved in nociception which contributes to the detection of noxious stimuli and transmits the signal to the central nervous system. Researchers believe it functions as a single unit without forming part of a larger protein complex. TGR7 modulates the pathways involved in pain perception and inflammatory responses.
Pathways
TGR7 is involved in the pain and inflammation pathways. It interacts with multiple intracellular signaling proteins such as G-proteins that relay signals leading to physiological responses. The receptor shares connections with proteins like TRPV1 which also participate in pain signaling pathways. These pathways highlight TGR7's critical role in translating external stimuli into cellular responses.
Researchers link TGR7 to conditions like chronic pain and neuropathic disorders. By modulating signaling involved in pain pathways TGR7 can influence the development or perception of chronic pain states. This receptor connects to other GPCRs involved in pain mechanisms suggesting potential therapeutic targets for drug development. Better understanding TGR7's role in these disorders could contribute to advanced treatments targeting pain management.