Abcam, ab165117, Recombinant Human ART5 protein

Size: 10µg
Recombinant Human ART5 protein is a Human Full Length protein, in the 1 to 292 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q96L15,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ART5 also known as ADP-ribosyltransferase 5 is a GPI-anchored cell surface protein. Its approximate mass is around 34 kDa. ART5 expression occurs mainly on the surface of leukocytes and other immune cells indicating its role in immune function. It localizes on the cell membrane which supports its involvement in cell signaling activities.
Biological function summary
ART5 plays a role in the modification of proteins through ADP-ribosylation which is important for signaling and regulatory processes. As part of a larger group of ADP-ribosyltransferases it can modify target proteins by adding ADP-ribose. This modification can affect the activity localization or stability of proteins impacting various cellular processes. Through these actions ART5 contributes to immune responses by influencing cell communication and signal transduction.
Pathways
ART5 influences signaling pathways associated with immune responses. It plays a role in the ADP-ribosylation pathway which involves various immune signaling molecules. Other related proteins involved in this pathway include CD38 and CD157 which also participate in ADP-ribosylation processes. These interactions underline ART5's involvement in regulating immune cell activities and responses.
ART5 has been connected to specific immune-related conditions. Its activity or regulation may contribute to autoimmune disorders and inflammatory diseases. ART5 interacts with proteins such as TNF-alpha a cytokine involved in inflammation which hints at its role in modulating inflammatory pathways. Dysregulated ART5 activity could enhance or suppress immune responses affecting how diseases manifest or progress.