Abcam, ab165424, Recombinant Human Olfactory receptor 13C8 protein

Size: 10µg
Recombinant Human Olfactory receptor 13C8 protein is a Human Full Length protein, in the 1 to 320 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q8NGS7,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Olfactory Receptor 13C8 often referred to as OR13C8 functions as part of the G-protein coupled receptor (GPCR) family specifically within the olfactory system. This protein facilitates the detection of odorant molecules by binding to them initiating a signal transduction pathway that results in the perception of smell. The molecular mass of OR13C8 is approximately 34 kDa. OR13C8 is expressed in the olfactory epithelium where it plays a role in the complex mechanism of olfactory sensation helping organisms to interact with their environment through the detection of chemical signals.
Biological function summary
Olfactory receptors like OR13C8 contribute to the sense of smell. They are integral components of the olfactory sensory neurons within the nasal cavity. These receptors form part of a larger network of olfactory receptor proteins that collaboratively recognize a wide array of odorant molecules. This recognition involves OR13C8 binding to specific volatile compounds which triggers a cascade of intracellular events involving G-proteins leading to neuronal activation and the transmission of electrical signals to the brain.
Pathways
This receptor partakes in the olfactory signaling pathway an important process for odor signal transduction. This pathway operates through interactions with G-proteins primarily influencing cyclic AMP levels in the olfactory neurons. Additionally OR13C8 might link to other GPCR-related pathways sharing functional relationships with other olfactory receptors that modulate these biochemical interactions and pathways providing a broader understanding of sensory signal processing.
Alterations in the activity or expression of OR13C8 may have a correlation with conditions such as anosmia or other smell-related dysfunctions. Misregulated expression of olfactory receptors like OR13C8 can impact neural processing potentially linking to neurodegenerative diseases where olfactory impairments are common early symptoms. Connections with proteins like adenylate cyclase involved in cAMP production suggest a broader relevance to understanding disease mechanisms and potential therapeutic targets in disorders affecting the sensory systems.