Abcam, ab166329, Recombinant Human CATSPER3 protein

Size: 10µg
Recombinant Human CATSPER3 protein is a Human Fragment protein, in the 299 to 398 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q86XQ3,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CATSPER3 also known as Cation Channel Sperm-Associated Protein 3 functions primarily as a calcium selective ion channel. This protein with a molecular weight of approximately 85 kDa forms part of the CATSPER channel complex located on the flagellar membrane of sperm cells. Expression of CATSPER3 occurs mainly in the testis. The channel plays a critical role in mediating calcium influx necessary for sperm motility and fertilization capabilities.
Biological function summary
CATSPER3 contributes significantly to sperm function. It forms a complex with other CATSPER proteins — CATSPER1 CATSPER2 and CATSPER4 — that combine to create a functional ion channel. This channel regulates calcium entry in response to triggers such as progesterone important for hyperactivation of sperm cells an enhanced motility state that facilitates penetration through the egg's zona pellucida. Disruption in any part of this complex impairs sperm function and can affect fertility.
Pathways
CATSPER3 operates within the pathway controlling sperm motility often influenced by the CatSper signaling pathway. This pathway governs calcium ion entry a pivotal event for initiating and sustaining sperm hyperactivated motility. CATSPER3 interacts closely with accessory proteins including CATSPERβ and CATSPERG supporting proper localization and functioning of the CATSPER ion channel within the sperm tail.
CATSPER3 has associations with male infertility particularly in cases related to asthenozoospermia a condition marked by reduced sperm motility. The protein interacts with other CATSPER proteins and mutations in CATSPER1 or CATSPER2 are also linked to similar fertility issues. The importance of CATSPER3 in regulating sperm motility stresses its role in reproductive health with dysfunctions potentially leading to subfertility or infertility in males.