Abcam, ab167017, Anti-P311 antibody

Size: 50µL
Rabbit Polyclonal P311 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NREP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NREP. The exact immunogen used to generate this antibody is proprietary information.Q16612

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein P311 also known as PTZ17 or NREP (neuronal regeneration-related protein) plays a role in cell migration and tissue repair. It has a molecular mass of approximately 8 kDa. You can find P311 mainly in the brain though it is also present in other tissues like skin and lung. This protein acts by modulating the cytoskeletal organization which is essential for its functions in different types of cells.
Biological function summary
P311 affects cellular processes such as muscle regeneration and neuronal development. It does not form part of a larger protein complex but interacts directly with different signaling pathways aiding cell motility and growth. P311 keeps a high expression during the early stages of cell differentiation further showing its role in developmental biology.
Pathways
P311 fits into the transforming growth factor-beta (TGF-β) signaling pathway influencing wound healing and inflammatory responses. It interacts with proteins involved in this pathway such as TGF-β1 and SMAD proteins. P311 also modulates the Rho GTPase signaling pathway which controls actin cytoskeletal dynamics suggesting its importance in cell motility and morphology.
P311 shows relevance to conditions like cancer metastasis and fibrosis. Its upregulation links with increased metastatic potential in various cancer types. Furthermore P311 connects with TGF-β an important player in fibrotic diseases such as pulmonary fibrosis highlighting its impact on disease processes. Understanding P311's role in these conditions could provide new therapeutic targets for disease intervention and management.