Abcam, ab167164, Anti-RBM47 antibody [EPR9658]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RBM47 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 10 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9658,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RBM47 also known as RNA-binding motif protein 47 plays a role in post-transcriptional gene regulation. It is a protein that weighs approximately 72 kDa. Researchers have found RBM47 mainly in the nucleus and its expression is observed in various tissues with higher levels in liver and kidney. This protein binds to RNA sequences and influences mRNA stability and splicing impacting gene expression.
Biological function summary
RBM47 contributes to RNA processing and modulation of mRNA splicing. It acts independently as well as part of larger protein complexes involved in RNA metabolism. This modulation can lead to variations in protein expression which is important for cellular differentiation and response. Studies indicate that RBM47 can interact with other RNA-binding proteins such as HuR which work together to stabilize specific mRNA transcripts.
Pathways
Studies associate RBM47 directly with the regulation of RNA stability and processing pathways. Notably it participates in pathways influencing the epithelial-mesenchymal transition (EMT) a process significant in cancer progression and metastasis. Within these pathways RBM47 works in conjunction with other RNA-binding proteins to maintain balance in RNA turnover and protein expression.
RBM47 has a connection to cancer and developmental abnormalities. Its role in modifying RNA transcripts and involvement in EMT suggest it might influence cancer cell metastasis. Decreased expression of RBM47 may relate to increased cancer aggressiveness. Additionally RBM47's interactions with proteins in the RNA stability pathway highlight its potential contribution to neural developmental disorders although the precise mechanisms require further research.