Abcam, ab167660, Anti-Tensin 1 antibody

Size: 50µg
Mouse Polyclonal Tensin 1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNS1 aa 1-400.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TNS1 aa 1-400. The exact immunogen used to generate this antibody is proprietary information.Q9HBL0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tensin 1 also known as TNS1 is a protein involved in focal adhesion dynamics and has a molecular mass of approximately 220 kDa. It belongs to the tensin family of proteins and plays essential role in linking the cytoskeleton to the extracellular matrix. Tensin 1 is mainly expressed in tissues like muscle brain and kidney suggesting its importance in maintaining cellular structure and function in these areas. The protein contains various domains including SH2 and PTEN-like regions which facilitate its multifunctional roles within the cell.
Biological function summary
Tensin 1 aids in the regulation of actin cytoskeleton organization and cell migration through its interactions with other cellular components. It participates as a component of the larger focal adhesion complex where it links integrins to the actin cytoskeleton. This connection is important for conveying mechanical signals from the extracellular environment which influence cellular movement and attachment. Tensin 1 also contributes to the modulation of cellular signaling pathways that regulate cytoskeletal remodeling impacting cell shape and motility.
Pathways
Tensin 1 plays a role in focal adhesion and integrin signaling pathways. These pathways are critical for cellular communication with the extracellular matrix and involve proteins such as FAK (Focal Adhesion Kinase) and Paxillin. Within these pathways Tensin 1 interacts with other focal adhesion proteins to influence cell survival and migration processes. Its role in these signaling pathways highlights its function in transmitting signals that control cellular dynamics and adhesion.
Researchers link Tensin 1 to conditions such as cancer and kidney disease. Altered expression or mutations of Tensin 1 correlate with increased tumor invasiveness and metastasis likely due to its influence on cell migration and adhesion. Furthermore abnormalities in Tensin 1 expression affect kidney function potentially contributing to chronic kidney disease development. In these diseases Tensin 1 interacts with proteins like integrins and other focal adhesion components which are essential in the progression and pathology of these conditions.