Abcam, ab168339, Anti-DLGAP4 antibody [EPR10888]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DLGAP4 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10888,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.35% Sodium citrate, 0.17% Sodium chloride, 0.05% BSA, 0.03% EDTA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DLGAP4 also known as SAPAP4 or DAP4 plays a role as a scaffolding protein at the postsynaptic density of neurons where it interacts with other proteins to facilitate synaptic signaling. This protein has a molecular mass of approximately 107 kDa. Its expression is primarily found in the brain particularly in the cerebral cortex and the hippocampus which suggests a specific role in neuronal function and behavior regulation.
Biological function summary
DLGAP4 participates as part of a postsynaptic complex that includes members of the DLG (discs large) protein family. This association is important for organizing and maintaining the structure of synaptic connections. The protein contributes to regulating synapse organization and plasticity which are important for learning and memory processes. Additionally it mediates interactions between the postsynaptic density components and the actin cytoskeleton aiding in the structural stability of synapses.
Pathways
DLGAP4 acts within the glutamatergic signaling pathway where it influences the dynamics of glutamate receptors. It associates with proteins such as PSD-95 which are integral in coupling receptors and other signaling molecules. The involvement in this pathway highlights the role of DLGAP4 in modulating excitatory synaptic transmission and synaptic plasticity which are essential for cognitive functions.
Disruptions in DLGAP4 expression or function have been linked to neurological diseases like schizophrenia and autism spectrum disorder. Abnormalities in DLGAP4 may affect brain circuits responsible for these conditions. Within these contexts DLGAP4 interacts with other synaptic proteins such as SHANK3 which when mutated or dysfunctional contribute to the pathophysiology of these disorders. Understanding DLGAP4's interactions can help illuminate mechanisms underlying synaptic dysfunction in these diseases.