Abcam, ab168645, Anti-TC10 antibody

Size: 50µg
Mouse Polyclonal TC10 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Recombinant full length protein - Human, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RHOQ.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human RHOQ.P17081

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TC10 protein also known as RhoQ is a small GTPase belonging to the Rho family with a molecular mass of approximately 22 kDa. This protein functions as a molecular switch cycling between an active GTP-bound state and an inactive GDP-bound state. TC10 is mainly expressed in the brain but also found in adipose tissues and muscle cells. It plays important regulatory roles in organizing the actin cytoskeleton thereby influencing cell shape polarity and movement.
Biological function summary
TC10 influences various cellular processes including glucose transport vesicle trafficking and cell migration. This protein associates with other molecules to form complexes that help guide these events. By modulating the organization of the cytoskeleton TC10 indirectly affects processes such as endocytosis and exocytosis. The protein also interacts with multiple effector proteins which further diversifies its functional capacities in cellular signaling.
Pathways
The TC10 protein is involved in the insulin signaling pathway and the lipid signaling pathway. Within the insulin signaling pathway TC10 connects with important molecules such as insulin receptor substrates that help mediate glucose uptake by cells. It is also linked to related proteins like Cdc42 another Rho family member assisting in membrane trafficking and organization. These interactions highlight TC10's role in critical cellular signal transduction processes.
Research suggests that TC10 is associated with insulin resistance a condition that can lead to type 2 diabetes and with certain neurological disorders. In insulin resistance TC10's impaired signaling leads to decreased glucose uptake which can negatively affect cellular metabolism. Moreover its regulation may tightly link with proteins like PI3K linking disturbances in TC10 function with metabolic disorders. This association makes TC10 a protein of interest in understanding and treating related diseases.