Abcam, ab168968, Anti-TOSO antibody

Size: 50µg
Mouse Polyclonal TOSO antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FCMR.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human FCMR.O60667

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TOSO also known as FAIM3 or IGFRI acts as a receptor critically involved in the regulation of apoptosis and immune responses. This protein has an approximate molecular mass of 32 kDa. It is heavily expressed on the surface of various immune cells including T and B lymphocytes which are key components in the immune system. TOSO participates in the inhibition of apoptosis by blocking the apoptotic signaling pathway thereby ensuring the survival of immune cells under both normal and stressful conditions.
Biological function summary
TOSO functions by modulating the immune response and ensuring cell survival. It operates as part of a receptor complex that includes Fas Ligand (FasL) and influences the cellular response to apoptotic signals. TOSO's role in this complex helps control cell death which is essential for immune regulation and homeostasis. This control is necessary to prevent excessive immune responses that can damage healthy tissues while ensuring the elimination of infected or cancerous cells.
Pathways
TOSO participates in the apoptotic and immune signaling pathways. Within the apoptotic pathway TOSO interacts with the Fas/FasL system to modulate the susceptibility of cells to programmed cell death. In the immune signaling pathway it is connected with proteins like FLIP and Caspase-8 which are vital in regulating apoptosis and immune cell proliferation. These interactions ensure that cells can withstand apoptotic signals under physiological conditions.
Dysregulation of TOSO expression or function has been linked to autoimmune diseases and certain cancers. In autoimmune diseases such as rheumatoid arthritis altered TOSO levels can contribute to pathological immune cell survival exacerbating tissue damage. In cancers like lymphomas TOSO may help tumor cells escape apoptosis aiding in unchecked cell survival and tumor progression. The relationship between TOSO and disease highlights its potential as a therapeutic target alongside proteins like Bcl-2 which are also involved in cell survival and apoptosis regulation.