Abcam, ab169114, Anti-SLX4 antibody

Size: 50µg
Mouse Polyclonal SLX4 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLX4.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SLX4.Q8IY92

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLX4 also known as BTBD12 or FANCP serves as an important scaffold protein in DNA repair mechanisms. This protein has a molecular mass of approximately 217 kDa. SLX4 is expressed mainly in tissues with high cellular turnover such as the bone marrow lymphoid tissue and intestine. It acts by recruiting and coordinating different endonucleases including SLX1 MUS81-EME1 and XPF-ERCC1 which are necessary for resolving complex DNA structures during replication and repair processes.
Biological function summary
Within the context of cellular maintenance SLX4 plays a significant role in maintaining genome stability. It forms part of the SLX4 complex which is essential for the accurate processing of DNA during homologous recombination repair. The SLX4 complex is involved in the repair of DNA interstrand cross-links and stalled replication forks ensuring that the DNA damage is accurately resolved to prevent chromosomal instability. The protein supports the assembly of the complex at repair sites influencing the cellular response to DNA damage.
Pathways
SLX4 is critically involved in the DNA damage response and repair pathways. It participates in key DNA repair processes including the Fanconi anemia (FA) pathway and homologous recombination. Within these pathways SLX4 interacts closely with proteins like FANCA and FANCD2 which are components of the FA pathway. SLX4's participation ensures the proper coordination and function of these pathways facilitating the repair of complex DNA damage and maintaining the integrity of the genome.
SLX4 mutations associate strongly with Fanconi anemia a genetic disorder characterized by increased cancer risk and bone marrow failure. Patients with SLX4 deficiencies display a phenotype that suggests its importance in protecting against genomic instability. Through the FA pathway SLX4 interacts with proteins such as BRCA1 which also plays a role in breast cancer susceptibility. Mutations in SLX4 and disruptions in its interactions with these related proteins may increase genomic instability contributing to the development of cancer and other DNA repair-related disorders.