Abcam, ab169188, Anti-UBR3 antibody

Size: 50µg
Mouse Polyclonal UBR3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UBR3 aa 1100 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human UBR3 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6ZT12

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBR3 also known as UBR domain-containing protein 3 functions as an important E3 ubiquitin ligase within the N-end rule pathway. It has a molecular mass of approximately 200 kDa. UBR3 is widely expressed with significant expression in the brain heart and skeletal muscle tissues. The protein plays an important role in recognizing and tagging proteins that display destabilizing N-terminal residues for proteasomal degradation a process essential for maintaining protein homeostasis.
Biological function summary
This protein performs essential roles in protein quality control and turnover. UBR3 is part of the ubiquitin-proteasome system and forms part of larger ubiquitin ligase complexes. This system governs the degradation of most intracellular proteins regulating various cellular processes like cell cycle progression and apoptosis. It ensures that damaged or misfolded proteins which could disrupt cellular functions are promptly identified and degraded.
Pathways
The ubiquitin proteasome pathway is one of the most important biological frameworks involving UBR3. This pathway pivotal for regulating protein concentrations and controlling cellular functions connects UBR3 with other proteins such as UBR1 and UBR2 which together function in substrate recognition and ubiquitination. Additionally UBR3 is involved in the N-end rule pathway further tying it to numerous cellular activities related to protein synthesis modification and degradation.
Irregularities in UBR3 function could contribute to neurological conditions and muscular degenerative disorders. Altered activity or expression of UBR3 might lead to Neurological disorders such as certain types of ataxias possibly due to disrupted protein homeostasis in neurons. Connections with proteins like p53 in pathways regulated by ubiquitin ligases also implicate UBR3 in cancer where it could affect cell cycle control and apoptosis thereby influencing tumor growth and progression.