Abcam, ab169301, Anti-CEP57 antibody

Size: 50µg
Mouse Polyclonal CEP57 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CEP57.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CEP57.Q86XR8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP57 also known as Centrosomal Protein 57 or Translokin is a protein with a molecular mass of approximately 57 kDa. CEP57 plays an important mechanical role in the centrosome which is important for the organization of microtubules during cell division. This protein localizes in the centrosome area within the cell cytoplasm. Expression of CEP57 is widespread occurring in various tissues which suggests its function is significant in different cellular contexts.
Biological function summary
CEP57 is important for proper cell division and spindle pole formation. It interacts within a complex of centrosomal proteins playing roles in microtubule nucleation and stabilization. CEP57 also functions as a microtubule-binding protein aiding the accurate segregation of chromosomes during mitosis. By stabilizing microtubule-kinetochore attachments CEP57 ensures effective chromosomal distribution hence maintaining genomic integrity and preventing potential cellular abnormalities.
Pathways
CEP57 contributes significantly to the cell cycle and mitotic spindle organization pathways. It works alongside other centrosomal proteins such as CEP192 and γ-tubulin enhancing their interaction and stabilization of microtubules. CEP57 is also linked to the microtubule-organizing center integrating into pathways important for cell division and duplication processes which are central to maintaining cellular homeostasis and function.
Researchers have associated CEP57 with certain cancers and mosaic variegated aneuploidy syndrome. In cancer overexpression or altered function of CEP57 might lead to improper cell division contributing to tumorigenesis. Furthermore in mosaic variegated aneuploidy syndrome improper function of CEP57 leads to chromosomal instability and abnormal cell growth. CEP57 involvement in these diseases highlights its interactions with other proteins such as TP53 which also manages cell cycle regulation and genomic stability.