Abcam, ab169392, Anti-P2Y8 antibody

Size: 50µg
Mouse Polyclonal P2Y8 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human P2RY8.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human P2RY8.Q86VZ1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The P2Y8 receptor also known as GPR99 is a member of the G protein-coupled receptors (GPCRs) family and has an approximate molecular mass of 35 kDa. It is involved in mechanical signaling by binding with extracellular nucleotides such as ATP and UTP. These interactions lead to diverse cellular responses including alterations in intracellular calcium levels. The P2Y8 receptor shows expression in a variety of tissues including the immune system suggesting its role in immune regulation.
Biological function summary
The P2Y8 receptor acts as an immune modulator and can influence the activity of leukocytes. It contributes to the regulation of inflammatory responses and potentially modulates the proliferation and migration of immune cells. While not part of a large receptor complex P2Y8 affects cellular signal transduction playing an important role in processes requiring rapid cellular responses.
Pathways
The P2Y8 receptor participates prominently in the purinergic signaling pathway. This pathway is essential for various physiological processes including inflammation thrombosis and neurotransmission. P2Y8 also interacts with other purinergic receptors and proteins such as P2Y1 and P2Y2 further establishing its role in coordinating cellular responses through nucleotide signaling.
The P2Y8 receptor is connected to inflammatory diseases where aberrant signaling may lead to excessive or prolonged inflammation. Additionally alterations or disruptions in P2Y8 function have been implicated in certain autoimmune disorders. The receptor's link with proteins such as P2Y1 and P2X7 influences its involvement in these disease pathways potentially offering targets for therapeutic intervention and contributing to our understanding of disease mechanisms.