Abcam, ab169748, Anti-FGF1 alpha antibody

Size: 50µg
Mouse Polyclonal FGF1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human FGF1.P05230

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FGF1 alpha also known as fibroblast growth factor 1 or aFGF functions as an important mediator in cellular processes such as proliferation differentiation and angiogenesis. This protein with a mass of approximately 18 kDa binds to specific fibroblast growth factor receptors (FGFRs) and heparan sulfate proteoglycans to initiate signal transduction. FGF1 alpha expresses in various tissues including brain liver and heart and plays significant roles in development and tissue repair.
Biological function summary
FGF1 alpha facilitates critical cellular functions by promoting cellular growth and survival. It often associates with other members of the fibroblast growth factor family and signaling molecules to form complexes essential for signal cascade initiation. This protein supports cellular resilience under stress conditions and participates in a variety of cellular activities which include wound healing and neovascularization.
Pathways
FGF1 alpha plays a significant role in the MAPK/ERK and PI3K/Akt signaling pathways. These pathways are fundamental for regulating cell cycle progression apoptosis and metabolic stability. FGF1 alpha interacts with proteins like FGF2 and FGFR1 which are involved in transmitting signals from the cell membrane to the nucleus impacting gene expression and cellular response.
FGF1 alpha is associated with cancer and metabolic disorders such as obesity-related insulin resistance. Its dysregulation or aberrant expression may result in uncontrolled cell growth typical of tumorigenic processes. FGF1 alpha often relates to FGF2 in oncogenic pathways where both proteins contribute to angiogenesis and tumor growth indicating their potential targets in therapeutic strategies for cancer treatment.