Abcam, ab170883, Anti-REPS2 antibody [EPR12033(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal REPS2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12033(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
REPS2 also known as RalBP1-associated Eps domain-containing protein 2 is a multifunctional protein with a role in endocytic membrane trafficking. You can find REPS2 expressed in various tissues with higher levels noted in brain and testis. The protein has a mass of approximately 80 kDa. Mechanically REPS2 acts in the intracellular trafficking pathways by binding to adaptor protein complexes which facilitates the sorting of molecules. It has a Ral-binding activity that influences its interaction with other cellular components.
Biological function summary
The cellular functioning of REPS2 is associated with the regulation of complex intracellular signaling networks. For example it associates with Ral GTPases thereby modulating cytoskeletal dynamics and endocytosis. This protein plays an important role in the regulation of cellular processes such as vesicle formation and transport impacting cell growth and survival. Its ability to interact with RalBP1 and other proteins highlights its importance in multiple cellular contexts.
Pathways
REPS2 functions as an essential component of signaling pathways regulating cellular trafficking and membrane dynamics. The Ral signaling pathway in which REPS2 participates is important for cytoskeletal organization and cellular proliferation. It also interacts with EGF receptor pathways underlining its role in modulating cellular responses to external signals. Through these connections REPS2 integrates external cues into cellular behavior adjustments often in cooperation with proteins like RalA and RalB.
REPS2 has been linked to cancer progression including prostate cancer and breast cancer. Abnormal expression or mutation of this protein may disrupt cellular trafficking or signaling pathways contributing to tumorigenesis. Moreover its interaction with RalBP1 and Ral GTPases has implications in the regulation of apoptosis and cytoskeletal organization factors critical in cancer metastasis. Understanding the role of REPS2 in these pathologies could provide insights into new therapeutic targets or interventions.