Abcam, ab170897, Anti-FOXB2 antibody [EPR11476]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FOXB2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11476,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXB2 also known as Forkhead box protein B2 is a transcription factor belonging to the forkhead family of proteins. This protein weighs approximately 36 kDa. Researchers found FOXB2 expressed in various human tissues though mainly in the brain and lungs. It plays a critical role in gene expression regulation binding to DNA and influencing transcriptional activity through its conserved forkhead domain.
Biological function summary
The forkhead domain of FOXB2 enables it to perform transcriptional regulatory functions affecting cellular processes like differentiation and development. FOXB2 does not typically form part of a larger protein complex though its function may depend on interactions with other transcriptional regulators. Its activity directly influences genes involved in cell proliferation and specialization suggesting a role in developmental programming.
Pathways
FOXB2 is involved in pathways related to cell growth and transcription regulation. It plays a role in the Notch signaling pathway interacting with proteins like Notch receptor to dictate cellular fate decisions. Additionally FOXB2 contributes to the regulation of TGF-beta signaling which involves SMAD proteins known to play roles in diverse cellular processes like immunity and cancer progression.
FOXB2 alterations have associations with cancer particularly in brain and lung tissues suggesting it might act as a potential oncogene. Moreover researchers explore its links to developmental disorders due to its expression patterns in embryonic tissues. Diseases like glioblastoma highlight its interaction with signaling proteins that manage cell cycle regulation making it a factor of interest in oncology research.