Abcam, ab170934, Anti-TH1L antibody [EPR11594]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TH1L antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11594,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TH1L also known as Mediator Complex Subunit 22 (MED22) is a mechanically important component of the mediator complex a multi-protein structure that acts as a bridge between gene-specific transcription factors and the RNA polymerase II enzyme facilitating the transcription of messenger RNA. TH1L has a molecular weight of approximately 36 kDa. It is predominantly expressed in the nucleus of various cell types often in actively dividing or metabolically active tissues.
Biological function summary
The role of TH1L extends beyond just a mechanical scaffold. As part of the mediator complex TH1L plays an important role in regulating gene expression by interacting with transcriptional activators and repressors. It integrates signals from transcription factors and conveys them to the transcriptional machinery thereby influencing which genes are turned on or off. TH1L is instrumental in the coordinated control of gene expression impacting diverse biological processes such as cell growth differentiation and response to external stimuli.
Pathways
TH1L's involvement is significant in the Notch signaling pathway and the Wnt signaling pathway both important for cell fate determination and proliferation. In the Notch pathway TH1L helps regulate the transcription of target genes by modulating the activity of the Notch intracellular domain. In the Wnt signaling TH1L assists in the transcriptional regulation by interacting with transcription factors like TCF/LEF that respond to Wnt signals. These pathways form a complex network of protein interactions with TH1L working in conjunction with other proteins like SMAD and β-catenin to fine-tune gene expression outcomes.
Research indicates TH1L involvement in cancer and autoimmune disorders. In certain cancers such as breast and prostate cancer dysregulation of TH1L leads to aberrant gene expression profiles that promote tumorigenesis. The abnormal function of TH1L through its interactions with oncogenic proteins like MYC can accelerate cell proliferation. In autoimmune disorders misregulation of TH1L may alter immune cell activity linking it to proteins involved in the immune response like NF-κB exacerbating the inappropriate immune activation that characterizes these conditions.