Abcam, ab171919, Anti-IFI27 antibody

Size: 100µg
Rabbit Polyclonal IFI27 antibody. Suitable for WB and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IFI27.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human IFI27.P40305

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IFI27 also known as Interferon alpha-inducible protein 27 is a small protein with a molecular mass of around 12 kilodaltons. This protein is expressed predominantly in response to type I interferons and some other stimuli. It mainly appears in tissues like the skin and liver which are involved in immune responses. IFI27 localizes to the mitochondria suggesting its role in regulating cellular apoptosis.
Biological function summary
IFI27 plays a significant role in mediating apoptosis the programmed cell death essential for normal cellular turnover and homeostasis. Although it does not typically form part of a larger protein complex its induction by interferons implicates it in antiviral defense mechanisms. Its expression can lead to changes in mitochondrial membrane potential ultimately affecting cell survival.
Pathways
IFI27 participates in important pathways related to immunity and apoptosis. Particularly it engages in the interferon signaling pathway influencing the cellular defense against viral infections. It interacts with other proteins like STAT1 and STAT2 which are key transcription factors in the interferon signaling cascade modulating downstream antiviral responses.
IFI27 has associations with chronic liver diseases and certain autoimmune conditions such as systemic lupus erythematosus (SLE). Its elevated expression often indicates an active immune response or cellular stress. IFI27's expression relates to IFI6 another interferon-inducible protein both of which are implicated in the cellular responses observed in these conditions. Understanding IFI27's role may help in developing therapeutic strategies for targeting immune-related disorders.