Abcam, ab17202, Anti-PICP antibody [8]

Size: 100µL
Mouse Monoclonal COL1A1 antibody. Suitable for IP, ELISA, sELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human COL1A1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:8,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:ELISA, sELISA, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human COL1A1.P02452,
Specificity:ab17202 is specific for native PICP from amniotic fluid.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, 2.9% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PICP also known as procollagen type 1 C-peptide or collagen C-peptide is a byproduct released during the synthesis of type I collagen. Type I collagen is the most abundant collagen type in the human body providing structure to skin bone tendons and other connective tissues. PICP has a molecular mass of approximately 35-38 kDa. It is expressed in tissues where type I collagen is synthesized including bone and skin fibroblasts.
Biological function summary
PICP serves as a marker for collagen biosynthesis closely reflecting the rate of collagen type I production. PICP does not form part of a larger complex but exists as a separate entity once cleaved from procollagen. Its presence in the bloodstream allows researchers to monitor collagen turnover which is vital in understanding tissue formation and remodeling processes.
Pathways
PICP connects with collagen synthesis and deposition pathways particularly relevant in bone formation and skin repair. It interacts indirectly with proteins like collagenase during collagen degradation and remodeling. Increased PICP levels indicate heightened collagen synthesis correlating with anabolic processes especially in bone metabolism pathways.
PICP levels are significant in bone-related conditions like osteoporosis where decreased collagen synthesis is often observed. It also correlates with fibrotic conditions including liver fibrosis where elevated collagen production marks disease progression. In these contexts PICP relates to other proteins such as procollagen type III N-peptide (PIIINP) which also serve as markers of pathological collagen deposition.