Abcam, ab172633, Anti-ARVCF antibody [EPR10036(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ARVCF antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10036(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARVCF also known as Armadillo Repeat gene deleted in Velo-Cardio-Facial Syndrome encodes a protein involved in cell adhesion and signaling. This protein weighs around 86 kDa and contains armadillo repeat domains facilitating interactions with other membrane-associated proteins. ARVCF is expressed in various tissues including the heart and brain suggesting its versatile role in cellular functioning. Localization in adherens junctions indicates its importance in maintaining structural integrity.
Biological function summary
The function of ARVCF supports cell adhesion and communication. It participates in complex formation with catenins and cadherins which are critical for adherens junctions. These complexes enable the anchoring of cytoskeletal elements to the cell membrane aiding in stable cell-cell contact. ARVCF modulates the transduction of signals that regulate cellular behaviors such as migration and proliferation through these interactions.
Pathways
ARVCF plays a role in Wnt signaling and adherens junction pathways. The protein interacts with β-catenin a significant player in Wnt pathway influencing gene expression related to cell growth and differentiation. ARVCF also associates with proteins involved in the assembly and maintenance of adherens junctions further emphasizing its connection to cellular architecture and signaling.
ARVCF has been linked to velo-cardio-facial syndrome and some forms of cancer. These associations suggest a connection between ARVCF dysfunction and disruptions in normal cell signaling and adhesion processes. In cancer altered ARVCF expression can impact the interaction with β-catenin and other junction-related proteins potentially influencing tumor progression and metastasis.