Abcam, ab173457, Anti-CCDC88B antibody

Size: 50µg
Mouse Polyclonal CCDC88B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CCDC88B aa 450 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CCDC88B aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.A6NC98

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CCDC88B protein also known by the alternate name "GIV" mechanically functions as a coiled-coil domain-containing protein. It has a molecular mass of approximately 164 kDa. This protein is mainly expressed in immune cells such as T cells and dendritic cells. CCDC88B plays a role in the intracellular signaling processes which are important for the regulation and expression of genes within these cells.
Biological function summary
The CCDC88B protein contributes to the immune response by modulating the signaling pathways that activate immune cells. It does not exist as a part of a larger protein complex but influences the activity of signaling complexes. The modulation by CCDC88B enhances immune cell survival growth and differentiation. Through its interaction with other signaling proteins it ensures an appropriate immune response to various stimuli.
Pathways
The CCDC88B protein acts within the Wnt signaling and NF-kB pathways. In the Wnt signaling pathway CCDC88B affects the regulation of gene expression cell behavior and immune cell responses. It interacts with other proteins in these pathways such as Dishevelled (DVL) in the Wnt pathway influencing the cascade of signaling events. By serving a critical function here CCDC88B helps in controlling cellular dynamics and immune reactions.
CCDC88B shows a notable connection with autoimmune disorders and inflammatory diseases. Dysregulation of CCDC88B expression or function can contribute to conditions like multiple sclerosis and rheumatoid arthritis. The protein's interaction with RelB a member of the NF-kB signaling pathway can have implications in these diseases affecting the immune system's balance. Certain therapeutic approaches explore targeting CCDC88B to restore immune function and ameliorate such autoimmune and inflammatory conditions.