Abcam, ab173581, Anti-CATSPERG antibody [EPR11608]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CATSPERG antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11608,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CATSPERG also known as Cation channel sperm-associated protein subunit gamma is a protein that plays an important role in the function of sperm. This protein is about 21 kDa in mass and is expressed specifically in the testis. CATSPERG forms a part of a voltage-gated calcium channel complex that is essential for sperm motility. The unique expression and functional attributes of CATSPERG suggest its central role in reproductive processes.
Biological function summary
The CATSPERG protein interacts with other channel components to modulate calcium entry into sperm cells. CATSPERG forms a complex with other subunits including CATSPER1 CATSPER2 CATSPER3 and CATSPER4 in the sperm flagellum. The complex ensures a controlled flow of calcium ions which is important for various aspects of sperm motility including hyperactivation and the acrosome reaction. These processes are essential for successful fertilization as they enable sperm to penetrate and fertilize the egg.
Pathways
CATSPERG integrates into the CatSper channel complex pathway which is important for generating the calcium ion influx required for sperm motility. This channel pathway relies on the orchestrated function of CATSPERG with associated proteins such as calmodulin and protein kinase A which further regulate sperm motility and fertility. By affecting calcium ion levels CATSPERG indirectly influences processes like signal transduction during sperm capacitation.
Defects in the CATSPERG gene or protein function can link to male infertility due to altered sperm motility. Studies connect disruptions in the CatSper channel complex including CATSPERG with certain types of asthenozoospermia a condition characterized by reduced sperm motility. CATSPERG's relation to other CatSper subunits can help identify potential targets for therapy aimed at treating specific infertility issues.