Abcam, ab174303, Anti-TRNP1 antibody [EPR11958]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TRNP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR11958,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRNP1 also known as Ternary Complex Factor Small Nuclear Ribonucleic Protein 1 is a protein involved in DNA-binding activities. It has a mass of approximately 25 kDa. TRNP1 is expressed in various tissues most predominantly in the brain and neural tissues. It acts as a transcription factor binding to specific DNA sequences and influences the expression of genes involved in brain development and neural cell proliferation.
Biological function summary
TRNP1 regulates the proliferation and differentiation of neural progenitor cells. This protein does not appear to form part of a larger protein complex but it directly affects cellular processes that shape the growth and arrangement of the cerebral cortex during embryonic development. Its expression levels can control the cellular architecture influencing neural tube closure and cortical folding.
Pathways
TRNP1 plays a role in neural development pathways and interacts significantly with the Wnt signaling pathway. It regulates genes that are important for maintaining the balance between neural progenitor cell proliferation and differentiation. In this pathway TRNP1 may have an interaction with proteins like Wnt and β-catenin that control cellular growth decisions affecting brain size and function eventually.
Alterations in TRNP1 levels or function relate to disorders such as microcephaly and possibly certain neurodevelopmental dysplasias. It has been suggested that imbalances in TRNP1 activity can disrupt cortical development leading to abnormal brain development. While comprehensive studies are ongoing TRNP1 potentially interacts with proteins associated with these disorders marking its importance in neural developmental research.